There's a conversation between two guards in the attic in Paris about multiverse theory that I think is a hint about how to think about all the different opportunities and targets on these maps.
I think we have one main canon story and the others exist in some sort of alternate timeline. In the timeline where the congressman is the target, 47 does not go on the mission to kill Silvio and Francesca. Maybe their plans to kill each other come to pass instead.
It would be pretty silly for future Sapienza elusive target #5 to take that trip to the small town where any one with a high profile is getting efficiently murdered.
Paris is set during an event rather than any typical day like in Sapienza. Which makes me think these stories are not on the same timeline.
It would be sweet, though, if a future target was someone from one of these organizations coming to deal with the aftermath of the hit.