His cheekbones are really high and extremely defined. (A characteristic in Asian or Amerindian or African people) White peoples cheekbones are usually less defined. Also his nose bridge isn't as defined in this picture which was also a characteristic on the alpha in-game model but I've noticed they've changed that part of his faced so now his nose bridge became more defined. A less defined nose bridge makes a face either appear Asian or Black.
These are general guidelines when you try to either draw or sculpt a face. Certain facial characteristics generally demonstrate a certain racial or ethnic group.
I can also understand how 47's pale skin and blue eyes could distract from his other subtle features and give you the overal appearance of a white male. Also he does have hooded eyes (don't confuse this with monolids those are completely different things) which are an eye shape commonly seen on white men and women especially when they age. To me his face always looked a little ambiguous but still mostly white.