One of the things the PC version of Absolution fell short on was it you couldn’t adjust your walk/crouch speed like you could do with a controller on a console.
Without this advantage on PC it became an annoyance of following NPCs that walked so much slower than you who would stop every time you got too close or end up bumping into them all because of you can’t keep a steady pace with them.
Following Kalvin Ritter as hes escorting you (disguised as Norfolk) to his room in the yacht mission is a fine example of this. it became of having to awkwardly stop every few feet and it completely takes you out of the game.
Splinter Cell: Chaos Theory is one of that i can think of that takes advantage of the mouse wheel feature and I’m surprised it hasn’t caught on.
Another reason is this could be a fine alternative to the sneak mode mechanic that the previous Hitman entries had up to Blood Money.