Not necessarily. If the one(s) invading the safehouse are literally the entire outfit who found out about it and are eliminated, then there’s no one else.
Besides, in the real world, such an isolated yet upscale location would never be practical for a safehouse; eventually someone would be noticing plane arrivals to the area where targets were killed originating from a particular region, would scope out the airports in that region for any recurring travelers or vehicles being parked there regularly, do some background searches/follow them, and realize that a few days before every confirmed kill, this black car in wherever the safehouse is; lets say Romania for now to go with my theory, this car that goes to one of the country’s airports near the time of the killing always ends up traveling down this one particular road back into the deep woods. Hmmm, let’s see what’s back there. Or, let’s see what images that spy satellite I know how to hack into can tell me.
The point of a safehouse is that you’re only supposed to stay there temporarily, then get on the move again, which was what ICA encouraged its agents to do, and to not make said safehouse a big ostentatious mansion, but someplace small and not noticeable. That apartment that we automatically have a key to in Sapienza during World of Tomorrow; that is a practical safehouse. What 47 is living in in Freelancer isn’t a “safehouse”; it’s just his house. He’s bound to get found out sooner or later by staying there indefinitely.